What are the side effects of topotecan?
The major side effects of topotecan are:
- Myelosuppression
- Diarrhea
- Low blood counts
- Susceptibility to infection
Topotecan hydrochloride (trade name Hycamtin) is a chemotherapy agent that is a topoisomerase I inhibitor.
It is often used in the treatment of ovarian and lung cancers, as well as other cancer types.
Topotecan intercalates between DNA. This intercalation disrupts the DNA duplication machinery when it finds a site in the DNA where topotecan is intercalated. This disruption prevents DNA replication, and ultimately leads to cell death.
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