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Personalised Medicine
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Dame Deborah James, who died aged 40 of bowel cancer, spent the last 5 years of her life raising awareness about her type of cancer, but also fighting to make personalised medicine more widely available for cancer patients.
Personalized medicine is therapy customized for an individual and has become more readily available as the cost of gene sequencing has been significantly reduced. An example is when treatment is targeted to a specific type of cancer cells.
HealthPad had partnered with a consortium of leading cancer specialists to explain what personalised medicine means and what it can do for cancer patients.
The HealthPad Team would like to join the many people who have admired Dame Deborah for her courage and determination.
Thank you and farewell, BowelBabe.
#bowelbabe #damedeborahjames #personalisedmedicine
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Parkway Cancer Centre
Cancer Treatment CentreParkway Cancer Centre offers comprehensive cancer treatment in Singapore with a highly skilled, multi-disciplinary team comprising consultant medical specialists, nurses, counsellors and other para-medical professionals to meet the specific needs of cancer patients.
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Ayaansh Hospital
Best Women's Cancer Hospital | Cancer Specialist in BangaloreAyaansh is the Best Women's Cancer Hospital in Bangalore to offer all types of Gyne Cancer Treatment by the Women's Cancer Specialist in Bangalore.
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- The burden of breast cancer throughout the world is significant and increasing
- Research has shown that a cheap pill (anastrozole) halves postmenopausal women’s risk of breast cancer and continues to be effective seven years after women stop taking the drug
- Anastrozole has fewer side-effects and is more effective than comparable treatments
- Government watchdogs both in the UK and US recommend anastrozole
- But the uptake of the drug in the UK is relatively low
- Doctors are not prescribing anastrozole and women are not availing themselves of the drug
- The UK’s NHS should employ new behavioural techniques to influence and change doctors’ and patients’ decisions and increase the uptake of anastrozole to reduce the burden of breast cancer
Will behavioural techniques improve breast cancer outcomes?
Research findings reported in the December 2019 edition of The Lancet and also presented at the December 2019 San Antonio Breast Cancer Symposium in Texas, show that a cheap pill, anastrozole, if taken once a day for 5 years, not only halves postmenopausal women’s risk of breast cancer, but continues to be effective seven years after stopping treatment, which for the first time, suggests a long-term benefit.
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Dr Mohit Saxena Cancer Specialist
Best Cancer Specialist GurgaonDr. Mohit brings,cancer specialist in Gurgaon has over 13 years of experience in oncology across some of the best hospitals in India such as Artemis Hospital (Gurgaon), VPS Rockland Hospitals (Manesar & New Delhi), Gujarat Cancer & Research Institute (Ahmedabad), and G.C.S. Medical College & Hospital (Ahmedabad). He completed his MBBS and MD in Medicine from Sawai Man Singh Medical College (Jaipur) and DM in Medical Oncology from Gujarat Cancer Research Institute (Ahmedabad). He holds a number of achievements, presentations and publications to his credit. His areas of interest include solid malignancies like breast, colon, lung, prostate, etc. and hematological malignancies like leukemias, lymphoma, and myeloma.
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Dr Rakesh Chopra Oncologist
Best Oncologist in GurgaonDr. Rakesh Chopra- Best surgical oncologist in Gurgaon, is among the pioneers of medical oncology in India with more than 43 years of extensive experience.
he had been a visiting fellow at multiple international universities and was awarded the prestigious fellowship ‘The Varoon Mahajan Foundation’ for study on Bone Marrow Transplant at the Memorial Sloane Kettering Cancer Center.
Dr Rakesh has exceptional expertise in solid cancers including breast cancer, cancers in women, and cancer of the lung, prostate & colon. He also specializes in hemato oncology.
He also specializes in precision cancer medicine, cancer genetics, palliative cancer treatment, and advanced chemotherapy treatment.
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- Bioengineers throughout the world are competing to achieve the Holy Grail: an affordable, point-of-care blood test - liquid biopsy - that detects cancer before any symptoms present
- Success in achieving this will save millions of lives, substantially reduce healthcare costs and make investors, researchers and organisations billions
- Despite significant advances no one has yet achieved the Holy Grail and there remains a substantial gap between researchers’ aspirations and reality
- How close are we?
Alfattani was presenting research findings of a small study at the National Cancer Research Institute’s (NCRI) conference in Glasgow, Scotland, in November 2019, which is an international forum for showcasing cancer advances.
A September 2019 HealthPad Commentary described another early detection test for breast cancer called CanRisk, which has been developed by researchers from Cambridge University’s Centre for Cancer Genetic Epidemiology and has the potential to identify women with different levels of risk of breast cancer.
Alfattani and bioengineers from the universities of Nottingham and Cambridge are players in a vast and rapidly evolving international army of researchers engaged in an intensely competitive global race to develop an affordable, point-of-care, early detection test (EDT) for cancer based upon a liquid biopsy and next generation sequencing technologies. The Holy Grail is for such a test to detect cancer cells in an asymptomatic patient, locate the tissue of origin and give that person an early diagnosis when treatment is more likely to be successful; and to do all this with 100% accuracy.
Although Alfattani’s research study is modest, her findings are potentially clinically relevant because they are on the Holy Grail therapeutic pathway, and her preliminary findings suggest that a simple, cheap and easy-to-use blood test - liquid biopsy - could detect breast cancer five years before any symptoms present. If demonstrated to be exquisitely accurate, safe and efficient by a larger study, which already is underway at Nottingham University’s CEAC, Alfattani’s research could be a key to saving thousands of lives and substantial amounts of money.
Gold standard breast cancer screening
In this Commentary
Partial epidemiology of breast cancer
Alfattani’s research
The Nottingham researchers took blood samples from 90 breast cancer patients at the time they were diagnosed with the disease and matched them with samples taken from 90 patients without breast cancer (the control group). Researchers employed technology (protein microarray), which allowed them to screen the blood samples for the presence of autoantibodies against 40 TAAs associated with breast cancer and also 27 TAAs not known to be linked with the disease. The accuracy of the test improved in the panels that contained more TAAs.
Findings
A panel of five TAAs correctly detected breast cancer in 29% of the samples from the cancer patients and correctly identified 84% of the control group as being cancer-free. A panel of seven TAAs was able to detect disease in 35% of cases with breast cancer and rule out 79% of patients in the control group. The most successful technique was a panel of nine antigens, which correctly identified the disease in 37% of cancer samples and no cancer in 79% of the controls. “The results of our study showed that breast cancer does induce autoantibodies against panels of specific tumour-associated antigens. . . . . The results are encouraging and indicate that it is possible to detect a signal for early breast cancer. Once we have improved the accuracy of the test, then it opens the possibility of using a simple blood test to improve early detection of the disease”, said Alfattani.
David Crosby, head of early detection at the Cancer Research UK charity, said, “Diagnosing cancer at the earliest stages before it grows or spreads gives patients the best chance that their treatment will be successful. So, the potential to detect markers in the blood before other signs appear is promising”.
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- CanRisk is a new online gene-based health-risk evaluation algorithm for detecting breast cancer
- It identifies people with different levels of risk of breast cancer, not just those at high risk
- As the infotech and biotech revolutions merge expect authority in medicine to be transferred to algorithms
- CanRisk has the potential to provide a cheap, rapid, non-invasive, highly sensitive and accurate diagnosis before symptoms present
- Breast cancer is the most common cancer in women worldwide and is the 5th most common cause of death from cancer in women
- Currently mammography screening, which has a sensitivity between 72% and 87%, is the gold standard for preventing and controlling breast cancer
- For every death from breast cancer that is prevented by screening, it is estimated there will be three false-positive cases that are detected and treated unnecessarily
- Lack of resources do not support breast cancer screening in many regions of the world where the incidence rates of the disease are rapidly increasing
- In the near-term expect interest in the CanRisk algorithm to increase
Although over the past two decades there have been significant improvements in the detection and treatment of breast cancer, the disease remains the most common cancer in women worldwide, with some 1.7m new cases diagnosed each year, which account for about 25% of all cancers in women and it is the fifth most common cause of death from cancer in women, with over 0.52m deaths each year.
When fully developed and approved, CanRisk will be well positioned to provide a cheap, rapid, non-invasive, highly sensitive and accurate diagnostic test to detect breast cancer early in people with diverse levels of risk. This might be expected to provide an alternative to the current gold standard population-based mammography screening and assist in making a significant dent in the vast and escalating global burden of the disease.
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Kapoor’s Kidney & Urostone Centre Pvt. Ltd.
Best Urologist Doctor in ChandigarhKapoor’s Kidney & Urostone Centre (KUC)–a premier Superspeciality Urology Hospital in Chandigarh. It is best kapoor nursing home Hospital which treats the many disease treatment in Chandigarh. Contact us now: 9915286238
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