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Pat O’Brien has been a Consultant & Honorary Senior Lecturer in Obstetrics and Gynaecology at University College London Hospitals since 1999. He is currently the Divisional Clinical Director for Women's Health. He specialises in Maternal Medicine and high-risk obstetrics, and at UCLH jointly runs a multi-disciplinary antenatal clinic involving consultants in Fetal Medicine, Cardiology, Haematology, Diabetes, Anaesthesia, and an Obstetric Physician. He has a particular interest in medical complications of pregnancy. He lectures widely in the UK and abroad, and runs courses on fetal monitoring, medical problems on the delivery suite, psychiatric problems and cardiac disorders in pregnancy.

He is the Chair of the International Division of the Institute for Women’s Health in London and a media spokesperson for the Royal College of Obstetricians & Gynaecologists. He is a reviewer for the Cochrane Collaboration and several medical journals. He sits on the Editorial Boards of the Journal of Obstetrics & Gynaecology and the BJM. He examines for the DRCOG examination. He has been a member of the obstetric guideline development group of the National Institute for Clinical Excellence in the UK. He also works regularly with BBC Television (British Broadcasting Corporation) as an obstetric advisor.