Disrupt or be Disrupted

  • AI-driven diagnostics, virtual care, and advanced analytics are transforming healthcare, enhancing outcomes and efficiency
  • To remain competitive, healthcare organisations must actively invest in digital transformation, forging strategic partnerships and embracing innovation
  • Leveraging AI and targeted M&A is essential for expanding capabilities, accelerating growth, and securing market leadership
  • This Commentary offers a strategic roadmap for capitalising on digital health, emphasising collaboration, talent development, and agility
 
Disrupt or be Disrupted

"We need to ensure that we have an environment here that’s conducive to creativity, to boldness, to new ideas, to recognising the dynamic world in which we live - one that is changing faster than it has ever changed before." These words, spoken by Marco Rubio on January 21, 2025, just hours after being sworn in as America’s Secretary of State, were meant to inspire diplomats navigating an unpredictable global landscape. Yet, they also serve as a clarion call for an industry at a crossroads - healthcare.

Healthcare is not immune to the forces of disruption. On the contrary, it is being upended by digital innovation at a pace that traditional institutions struggle to match. AI-powered diagnostics, virtual care platforms, precision medicine, and wearable biosensors are redefining how care is delivered, driving better patient outcomes, lowering costs, and expanding access. And yet, many of the boldest advancements - the very ones with the potential to reshape the industry - come not from established institutions but from start-ups, outsiders, and unorthodox thinkers.

These disrupters, often found at the periphery, are sometimes unpolished and undiplomatic. Lacking the silver tongue of seasoned executives and the political correctness of corporate boardrooms, they challenge long-held assumptions and force uncomfortable conversations. Their ideas can be raw, their methods unconventional, but their impact is valuable. However, since they are different to traditional norms - failing to align with established structures - they are often dismissed, marginalised, or resisted by incumbents who, whether knowingly or not, seek to preserve the status quo.

Yet, history has shown that industries that ignore or suppress disruption do so at their peril. The digital health revolution is not a passing trend but an irreversible shift, evidenced by ~$10bn in venture funding that flowed into health-tech start-ups in 2024 alone. The question for healthcare leaders is clear: Will they embrace the agents of change and harness their disruptive power or will they resist, only to find themselves disrupted?
 
In this Commentary

This Commentary explores the shift underway in healthcare as digital innovation redefines care delivery, operational models, and competitive dynamics. It explores the rise of AI, virtual care, and precision medicine, showcasing how disrupters - often start-ups and unconventional players - are reshaping traditional institutions. With billions in venture funding fuelling digital health, the Commentary urges healthcare leaders to adapt to disruption or risk being left behind in an increasingly tech-driven landscape.
 
Leveraging Disrupters

Revenue Diversification and Growth Opportunities
Healthcare organisations, whether providers, insurers, or technology developers, are operating in an era of significant change, driven by digital health innovations that are redefining traditional business models. Historically, the sector has been dominated by capital-intensive infrastructure and human-intensive processes, such as surgical interventions, diagnostic imaging, and administrative workflows. While these remain fundamental, the advent of software-driven solutions and data-centric care models presents new revenue opportunities that transcend conventional market limitations.

Start-ups have emerged as primary incubators for disruptive technologies, pioneering advancements in AI-enabled diagnostics, virtual care ecosystems, and remote patient monitoring. These innovations not only enhance clinical efficiency but also introduce scalable, subscription-based revenue models that provide long-term financial sustainability. Established enterprises that fail to integrate such advancements risk stagnation, while those that actively embrace disrupters are better positioned to leverage digital tools that can unlock new revenue streams, drive operational efficiencies, and enhance patient outcomes.

Investment trends affirm this paradigm shift. In 2024, funding for digital health spanned diverse clinical domains, from cardiovascular care to mental health, with start-ups securing billions. This underscores the investment community’s recognition of digital solutions and services as catalysts for growth. Healthcare incumbents must actively scout, partner with, or acquire disruptive players to mitigate reliance on legacy offerings and tap into high-growth market segments that promise sustained profitability.

Enhancing Valuations Through Innovation
In today’s investment landscape, entities within the sector are assessed not only on their present performance but also on their capacity for innovation and agility. Venture capital firms such as Andreesen Horowitz and General Catalyst are making decisive investments in AI platforms, recognising their ability to transform clinical workflows, improve patient engagement, and optimise financial outcomes. This trend signals a broader industry shift - companies that harness technologies command higher valuations and attract stronger investor interest.

For established enterprises, the case for digital transformation is not only strategic but financial. Mergers and acquisitions in this space have surged, with deals targeting AI-driven decision support, analytics-powered risk stratification, and virtual care infrastructure. These investments create synergies that enhance efficiency, strengthen market positioning, and elevate financial performance. Providers, insurers, and life sciences companies must rethink their innovation strategies - not just as an enhancement to existing operations but as a core driver of valuation and competitive differentiation.

Competitive Advantage in a Changing Landscape
Healthcare is witnessing an unprecedented shift, where agility and technological adoption define market leadership. Large incumbents often struggle with structural inertia, as long-tenured executives grapple with managing disrupters while prioritising the stewardship of legacy offerings in increasingly saturated markets. However, the rapid proliferation of digital health start-ups is reshaping competitive dynamics, and established enterprises that do not proactively engage with disrupters risk losing their competitive edge.

Start-ups are leading the charge in AI, telehealth, and remote patient monitoring, capturing ~37% of all digital health funding in 2024. This signals a market appetite for next-generation healthcare solutions. Forward-thinking enterprises must not only acknowledge but actively pursue collaboration, investment, or acquisition strategies that integrate these innovations into their existing frameworks.

Strategic alliances with disrupters accelerate the adoption of cutting-edge technologies, and reinforce an organisation’s reputation as a leader in innovation, attracting top talent, fostering investor confidence, and securing long-term competitive advantage.

Sustainability Through Innovation
Sustainability extends beyond financial and environmental considerations; it encompasses the capacity to continuously evolve while maintaining high standards of care. Digitalisation is redefining sustainability by addressing systemic challenges such as cost efficiency, equitable access, and resource optimisation.

AI-driven analytics enhance diagnostic accuracy and streamline workflows, allowing clinicians to focus on patient-centred care. Virtual care platforms eliminate geographical barriers, expanding access to underserved populations while reducing operational overhead. Predictive modelling empowers insurers and healthcare systems to implement proactive interventions, improving population health management and reducing unnecessary hospitalisations.

Additionally, the shift towards value-based care necessitates advanced technological capabilities to ensure compliance, optimise reimbursement structures, and improve care quality. Digital solutions facilitate real-time data capture, regulatory adherence, and personalised treatment pathways, positioning organisations for long-term resilience in a rapidly evolving regulatory environment.
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Key Trends

Early Investment Surge
In 2024, ~63% of funding rounds targeted early-stage start-ups, marking a significant increase from 2023. This surge highlights a pipeline of innovation driven by emerging companies. Stakeholders - ranging from providers and payers to technology vendors - should leverage this momentum by engaging with start-ups through strategic investments, partnerships, or incubation programmes. Early-stage investments offer a dual advantage: access to pioneering technologies and the opportunity to shape their development in alignment with industry needs.

Notable deals, such as Regard’s $61m Series B funding for clinical decision software, illustrate how established players can incorporate emerging solutions to enhance operational efficiency and patient outcomes. By collaborating with innovative start-ups, organisations can expand into high-growth areas such as decision support systems, patient engagement tools, and population health management.

AI’s Dominance in Healthcare Innovation
The investment trend we have highlighted shows the increasing acknowledgment of the transformative potential of AI. Advancements in this space span a wide range of applications, from optimising clinical workflows to enhancing patient-centric solutions. Trailblazers such as Hippocratic AI and Infinitus exemplify this momentum, offering technologies that simplify administrative tasks, improve diagnostic precision, and deliver personalised care with unprecedented efficiency.

Integrating AI into established portfolios is important. Whether through partnerships, acquisitions, or in-house development, AI can improve operational efficiencies, optimise resource allocation, and deliver more personalised and predictive care. Staying ahead in the AI race enables organisations to remain competitive and meet the evolving expectations of patients and providers.

Strategic M&A as a Growth Lever
M&A in digital health is accelerating as organisations seek solutions that address a broad spectrum of healthcare needs. Analysts predict that 2025 will bring an increased wave of M&A activity, offering opportunities for players to expand their capabilities through targeted acquisitions.

Examples like DarioHealth’s acquisition of Twill and Fabric Health’s series of strategic purchases demonstrate how M&A can create end-to-end virtual care platforms and broaden market reach. By adopting a similar approach, stakeholders can accelerate entry into high-demand segments such as telehealth, chronic care management, and AI-powered diagnostics, while creating synergies that enhance scalability and innovation.

The Rise of Smaller Market Opportunities
While large enterprises dominate the healthcare AI market, smaller start-ups are finding success by focusing on niche segments, including solutions tailored to small- and medium-sized practices. This trend opens new avenues for traditional players to diversify their offerings and serve underrepresented markets.

Organisations can capitalise on this by developing or acquiring technologies that cater to these specialised needs, strengthening their position in the broader ecosystem. Addressing niche markets not only diversifies revenue streams but also fosters deeper relationships with a wider range of healthcare providers, ensuring more equitable access to innovation.
 
A Roadmap for Enterprises
 
To capitalise on the transformative potential of digital health, organisations must embrace a structured yet adaptable approach - one that balances ambitious innovation with operational pragmatism. Crucially, this requires a willingness to engage with unconventional thinkers and disruptive technologies, even when they challenge traditional corporate cultures. The following roadmap outlines five essential steps to navigate this landscape effectively:

1. Define Strategic Objectives Enterprises must first identify high-impact priorities that leverage their core strengths while addressing pressing market needs. Whether it is optimising clinical workflows, deploying AI-driven predictive analytics, or expanding virtual care capabilities, these objectives should be grounded in data insights, market intelligence, and an awareness of industry shifts. The key is to ensure that investments drive meaningful, measurable outcomes rather than just becoming exercises in experimentation.

2. Foster Strategic Partnerships The pace of change demands collaboration across diverse stakeholders, from start-ups to research institutions and tech giants. Partnering with disruptive innovators - even those whose mindsets differ from conventional corporate paradigms - can accelerate development cycles, introduce fresh perspectives, and unlock novel approaches to patient engagement or operational efficiency. Beyond innovation, these alliances also help enterprises navigate regulatory challenges and enhance system interoperability, ensuring that emerging solutions integrate seamlessly into existing care frameworks.

3. Invest in Talent and Skills Development Transformation is as much about people as it is about technology. Enterprises must cultivate a workforce equipped with expertise in AI, cloud computing, data science, and healthcare informatics. This requires a multi-pronged approach: reskilling existing employees, recruiting domain specialists, and fostering a culture that values continuous learning and cross-disciplinary collaboration. Encouraging interaction between clinical and technical teams ensures that solutions remain grounded in the realities of care delivery, enhancing both adoption and long-term efficacy.

4. Leverage M&A for Strategic Advantage Acquiring innovative companies can provide a fast-track route to leadership in emerging domains such as cybersecurity, data integration, and patient-centric engagement platforms. A disciplined approach to M&A allows enterprises to complement organic innovation efforts, filling critical capability gaps while maintaining alignment with overarching business and care objectives. However, success in this arena depends not just on financial transactions but also on integrating acquired innovations in ways that preserve their disruptive potential rather than diluting it within rigid corporate structures.

5. Adopt Agile Operating Models Agility is essential in an environment where regulatory frameworks, technological advancements, and consumer expectations evolve rapidly. Enterprises must embrace iterative development, cross-functional collaboration, and rapid prototyping to ensure solutions remain adaptive, user-focused, and future-proof. Crucially, an agile mindset must extend beyond product development to enterprise-wide decision-making - enabling organisations to pivot swiftly in response to emerging trends and disruptive forces.

By adopting this roadmap, enterprises can unlock new frontiers in digital health, fostering innovation, enhancing care delivery, and driving sustainable growth. Success will depend not only on technological sophistication but also on a openness to new ways of thinking - particularly those introduced by disrupters who may not conform to legacy corporate norms but hold the key to the next breakthrough.
 
Takeaways

The time for cautious, incremental change in healthcare has passed. The digital health revolution is not a hypothetical future - it is happening now, and the stakes could not be higher. Organisations that fail to engage with disrupters will find themselves outpaced, outmanoeuvred, and ultimately obsolete in a market that rewards speed, innovation, and adaptability.

Healthcare leaders must reject the outdated notion that disruption is a threat to stability. Stability is an illusion in an industry undergoing significant changes. The true risk lies in standing still while the landscape transforms around you. The $10bn in venture funding that flooded digital health in 2024 is not just a financial trend - it is a signal that the future of healthcare belongs to those willing to think beyond the limits of legacy systems and embrace a new paradigm driven by AI, virtual care, and precision medicine.

The choice is clear: disrupt or be disrupted.

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