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tbc

The major side effects of topotecan are:

1. Myelosuppression
2. Diarrhea
3. Low blood counts
4. Susceptibility to infection

Topotecan hydrochloride (trade name Hycamtin) is a chemotherapy agent that is a topoisomerase I inhibitor.

 It is often used in the treatment of ovarian and lung cancers, as well as other cancer types.

Topotecan intercalates between DNA. This intercalation disrupts the DNA duplication machinery when it finds a site in the DNA where topotecan is intercalated. This disruption prevents DNA replication, and ultimately leads to cell death.

Cisplatin or cisplatinum (trade names Platinol) is a cytotoxic chemotherapy drug.

It is used to treat various types of cancers, including:

• sarcomas
• small cell lung cancer
• ovarian cancer
• lymphomas
• cervical cancer
• germ cell tumors.

Cisplatin was the first platinum-containing anti-cancer drugs, which now also includes carboplatin and oxaliplatin. These platinum complexes react in vivo, binding to and causing crosslinking of DNA, which ultimately triggers apoptosis (programmed cell death).

Side effects of Cisplatinum include:

• Nephrotoxicity (kidney damage)
• Neurotoxicity (nerve damage)
• Nausea and vomiting
• Ototoxicity (hearing loss)
• Electrolyte disturbance